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BMC Cancer 2013, 13:387 http://www.biomedcentral.com/1471-2407/13/Page 10 ofTable 3 Molecular fingerprint of LGGs composed by the selected 15 genes (Continued)APOD / 3q26.2qter PTGD2S / 9q34.2-34.three apolipoprotein D prostaglandin D2 synthase 21 kDa (brain) SDC3 / 1pter-p22.3 NRXN2 / 11q13 syndecan 3 neurexin two GO.0006629 lipid metabolic procedure GO:0006633 fatty acid biosynthetic procedure GO:0006810 transport GO:0007155 cell adhesion GO:0007268 synaptic tra.Signature primarily based on high-throughput procedures that offer a genome-wide snapshot of LGGs with respect to both distinct lesion web site inside the brain and histotype.Mascelli et al. BMC Cancer 2013, 13:387 http://www.biomedcentral.com/1471-2407/13/Page 9 ofTable three Molecular fingerprint of LGGs composed by the selected 15 genesGene/Locus FOXG1 / 14q13 Description forkhead box G1 Biological Method GO:0007417 CNS development GO:0022008 neurogenesis GO:0030900 forebrain development GO:0048699 generation of neurons GO:0021954 CNS neuron improvement GO:0021953 CNS neuron differentiation GO:0048666 neuron improvement GO:0007423 sensory organ improvement GO:0043583 ear development GO:0009953 dorsal/ventral pattern formation GO:0006355 regulation of transcription, DNA-dependent GO:0051252 regulation of RNA metabolic process GO:0045449 regulation of transcription GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048812 neuron projection morphogenesis GO:0048858 cell projection morphogenesis <a href="https://www.ncbi.nlm.nih.gov/pubmed/28499442" title=View Abstract(s)">PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28499442</a> GO:0032990 cell part morphogenesis GO:0031175 neuron projection development GPR17 / 2q21 G protein-coupled receptor 17 GO:0007165 signal trasduction GO:0007186 G-protein coupled receptor protein signaling pathway CXCL14 / 5q31 chemokine (C-X-C motif) ligand 14 ARX / Xp21 aristaless related homeobox GO:0006995 immune response GO: 0006935 chemotaxis GO:0007267 cell-cell signaling GO:0007165 signal trasduction GO:0007417 CNS improvement, GO:0022008 neurogenesis GO:0030900 forebrain improvement, GO:0048699 generation of neurons GO:0021954 CNS neuron improvement, GO:0021987 cerebral cortex development GO:0021543 pallium improvement GO:0006355 regulation of transcription, DNA-dependent GO:0051252 regulation of RNA <a href="http://www.ncbi.nlm.nih.gov/pubmed/27484364" title=View Abstract(s)">PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27484364</a> metabolic approach GO:0045449 regulation of transcription GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048812 neuron projection morphogenesis GO:0048858 cell projection morphogenesis GO:0032990 cell aspect morphogenesis GO:0031175 neuron projection development LHX2 / 9q33q34.1 LIM homeobox 2 GO:0007417 CNS improvement GO:0022008 neurogenesis GO:0030900 forebrain development GO:0048699 generation of neurons GO:0048666 neuron improvement GO:0009953 dorsal/ventral pattern formation GO:0006355 regulation of transcription, DNA-dependent GO:0051252 regulation of RNA metabolic method GO:0045449 regulation of transcription GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048812 neuron projection morphogenesis GO:0048858 cell projection morphogenesis GO:0032990 cell component morphogenesis, GO:0031175 neuron projection development TIMP4 / 3p25 TIMP metallopeptidase inhibitor four GO:0007417 CNS development GO:0009725 response to hormone stimulus GO:0032496 response to lipopolysaccharide GO:0034097 response to cytokine stimulusMascelli et al.

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